Contents

Effect of Refracterin on the Sympatho-Adrenergic System
in Patients with Chronic Heart Failure

A. Melia, Z. Klimiashvili, I. Lezhava, I. Kankava, N. Salibegashvili,
N. Karsanov Cardiological   clinic  "GULI"

Key words: chronic heart failure, sympato-adrenergic system, refracterin.

According to the data, sympatho-adrenergic system plays a leading role in progression of Chronic Heart Failure (CHF). The purpose of the study was to evaluate the effect of a new cardiotropic agent – refracterin- on the sympatho-adrenergic system in patients with CHF (NYHA II-IV class).

In total, 81 consecutive patients (mean age 55.2±4.2 yrs) who experienced MI  complicated with HF were divided into two groups: Gr. 1 - patients treated with conventional agents; and Gr. 2 - conventional treatment in combination with refracterin (iv infusion with 5% glucose). The study duration was 14 days. The study population underwent clinical-biochemical examination at entry and after the end of the study.

         Subsequently, post study data indicate that in Gr. 2 compared to Gr. 1, EF elevated by »5.4%, Opine index increased to normal and patients symptomatically felt better.  These data are in correlation with approximately two-fold increase in noradrelanin concentration, and elevation of noradrenalin/ adrenalin ratio  (r=-0.72 p<0.005) up to the lowest border of normal range.

In conclusion, addition of refracterin to traditional therapy improved sympatho-adrenergic functions, and, thus, clinical symptoms in our patients.  This may be due to antyoxidative, antyischaemic and antyhypoxemic effects of refracterin.

Literature:

1.        П. Х. Джанашия, О.В. Владицкая, Е.Я. Богданова и др., Росс. кардиол. журн., № 2, 11-16 (1999).

2.       Н. В. Карсанов, И. К. Джибгашвили, Г. В. Сукоян и др., Пат. физиол., №3, 3-8 (1999)

3.       В. Ю. Мареев, А.А. Скворцов, С.М. Челмакина и др., Кардиология, №2, 27-34 (1999).

4.       Л.И. Ольбинская, Росииск. Мед. вести, №2, 4-9, (2000).

5.       S.D. Anker, Eur. Heart J., 19 (suppl 4), F56-F61(1998).

6.       E. Iwai-kanai, K. Hasegava, M. Araki et al., Circulation, 100 (4), 305-311 (1999).

7.       A. M. Katz, N. Engl. J. Med., 322 (13), 100-110 (1990).

8.       J-L. Liu, I.H. Zucker, Circ. Res., 84 (4), 417-423 (1999).

9.       M. J. Sole, in E. Braunwald et al., (eds), Grune&Stratton, New York (!982).

10.    G.V. Sukoian, A. N. Melia,. Z. N. Klimiashvili et al., 29^th  European muscle conference, Berlin, Germany, 2000.

Contents