Relation of initial plasma data of anti inflammatory cytokine IL-10 with dynamics of disease And ischemic lesion size in acute phase of ischemic stroke. |
M.
Beridze, R. Shakarishvili |
Abstract:
The high levels of anti-inflammatory cytokine IL-10 is associated with
smaller infarct size in experimental models of brain ischemia. We aimed
to research the dynamic changes of blood IL-10 levels in acute stage of
ischemic stroke and correlation of IL-10 initial data with ischemic
lesion size. The levels of IL-10 were defined by application of ELISA
method. Lesion size was detected by conventional MRI scans. Results
revealed the negative correlation of IL-10 initial plasma levels with
ischemic lesion size. Dynamics of IL-10 plasma levels during one week
from ischemic stroke onset showed the association of reduced levels of
IL-10 after 1 week from stroke onset with neurological worsening. |
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