Some
clinical features of physical
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N.
Baqradze, G. Mamaladze, M. Magaldadze, M. Kufaradze, E. Tsatsanashvili, |
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The
aim of the present
study was to determine the pain perception threshold in silent myocardial
ischemia induced by physical load, and evaluate izosorbit dinitrat and
diltiazem effect on the pain perception. In total 145 male, non-diabetic
subjects were enrolled in the study. Based on the results of stress tests
patient were devided into 3 groups: Gr. 1, 45 patients (31.3%), mean age
50±4.6 yrs (30 pts>50 yrs, 15 pts<50 yrs) with ischemic
depression of ST segment on the stress ECG, no pain sensation. Gr.2, 60
patients (41.37%), mean age 42±5yrs (33pts>50yrs, 27 pts<50yrs)
in whom together with ischemia criteria angina development was registered.
Gr.3 40 patients (27.58%), mean age 45±6.2yrs (36 pts<50yrs, 4
pts>50yrs) with negative stress test results. Perception
threshold according to groups was as follows: Gr.1 14.5±2.2 sec; Gr.2
7.1±3.2 sec; Gr.3 5.1±4 sec. According to the age of the
patients we observed that in <50yrs age group perception threshold was
6.6±2.0 sec, while in >50yrs age group it was 12.8±4.5 sec. Arterial
hypertension was observed in 16 Gr.1, and 28 Gr.2 patients. We
registered than in the presence of arterial hypertension pain perception
index was 12.8±3.2 sec, while in its absence only 5.4±2.1 sec.
(P<0.05). The
results obtained indicate that in patients with silent ischemia on stress
ECG the pain perception threshold increased (from 6.7±1.67 to 15.1±1.9);
in patients with symptomatic myocardial ischemia on stress ECG the pain
perception threshold decreased (from 25.3±1 to 11.7±2.7). Treatment with
anaprilin and izosorbid dinitrate caused the increase in the pain
perception threshold, while diltiazem therapy had no effect on pain
perception.
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Cohn P.F Silent myocardial ischemia in patients with a defective
anginal warning system, Am J.cardiology 1980,45, 697-707 2.
Pascal
N Silent myocardial ischemia Adis international, chester 1991. 3.
Милвидаит
И.Ю.
Особенности
болевого
синдрома
при
стабильной
стенокардии
его
значение
для
прогнозирования
течения и
исходов
заболевания
Автореферат
Канд.
Дисерт.
Минск
1987 г. 168 4.
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