Protodiastolic
blood flow-factor for intimal damage |
F. Todua, M.
Beraia |
Purpose: It is now accepted that hemodynamic forces are localizing factors in pathogenesis, and the places characterized by low and oscillatory levels of wall share stress are preferentially sites for endothelial damage. Some of these alterations are not well understood. The aim of the study was to calculate blood flow features of the aortic arch for revealing flow patterns at the sites of vascular branching. Methods: 15 healthy persons were investigated on 1.5MR imager Siemens-Sonata Cardio-PC.MRA.fl2D,TR-47ms,TE-2.7ms.FoV.292.360.SL6.The patients’ age was within 25-37. Results: Places with systolic low peak velocity and low share stress acquire a high wall tensile stress. At the time of protodiastola, the blood flow at these places becomes retrograde. Tangential forces to the endothelium are correlated with blood acceleration, reached 32,3-43.0N/m2, and can damage endothelial sheet. Conclusion: Protodiastolic share stress at the places of vascular branching is the main factor for the endothelial damage for atherosclerosis. |
Literature:
8. Fung Y.C. “ Biomechanics, Circulation”, Second Edition, Springer-Verlag-, New York, 1997. |