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Cerebral blood flow circulation disorders:
pathogenic and compensatory mechanisms.

R.R. Shakarishvili, G. I. Mchedlishvili.

In the range of pathogenic and compensatory processes of cerebral hemodynamics the macro- and microcirculation mechanisms are differentiated creating the pathogenic background of

lacunar and watershed infarcts of the brain accordingly. Compensatory mechanisms of the brain macro circulation system are universal and represented by mobilization of collateral network and cerebrovascular auto regulation, while in the microcirculation system the main compensatory role plays the uniquely small diameter of cerebral capillaries restricting the invasion of aggressive cell substrates (thrombocytes, neutrophyles), the low capillary hematocryte, maintaining the stabile level even during significant changes of systematic one, as well as strengthening of oxygen extraction phase. The end-point of the combined pathogenic action of disorders of auto regulation and ,,no-reflow” phenomenon is considered to be the precapillary sector of microcirculation.

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