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Miocardial structural and metabolic changes in experimental
autoimmune cardiomiopathy
R. Kapanadze, Z. Topuria
Acad. M. Tsinamdzgvrishvili Institute of Cardiology

Autoimmune cardiomyopathy in rats was produced by simultaneous injection of myocardial homogenate and Friends adiucante in abdominal subdermal area. Electrocardiographical, hystological, hystoeazimochemical, electromicroscopical study of myocardium revealed morphological and functional changes in myocardium. The structural basis of autoimmune cardiomyopathy is being determined by primary damage of cardiomyocytes because of development of cross-type immune reaction. Development of focal hypertrophy and fibrous tissue formation is a response to this damage.

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