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The Effect of Perindporil on the Diastolic Function of the Left Ventricle in
The Early Period of Post Infarction Remodeling

I.Megreladze,  M.Gorgoshidze,  I.Cincadze,  L.Gujejiani

Cardiology Department of the State Medical Academy

Key words: Perindopril, diastolic function, remodeling, myocardial infarction.

During the period of remodeling, effect of Perindopril from the left ventricle on diastolic function were exa­mi­ned on 30 patients.

Impulsive Doppler Echocardiograpical method is used. Against the background of basic therapy, the treatment was provided with Perindporil 2-4mg, in 24 hours. Examination was made on patients within 10 days, from the development of myocardial infarction. Against the background of treatment with Perindopril, in the early period of myocardial  infarction, diastolic function of the left ventricular was keeping stability,  and during the transmural myocardial infarction I type of diastolic function existing in left ventricular got negative dynamics  in the 27% of events.

Reference:

1.        Митьков Б.Б. Сандриков Б.А. Клиническое руководство по ультразвуковой диагностике. ВИДАР, Моск­ва 1998.

2.        Cohn J.N.,  Archibald D.G. et al. Effect of vasodilator therapy on mortality in chronic congrestive heard Failu­re: result of a Veterans Administration Cooperative Study // N. Engl. J. Med. 1986, 314, 1547-1556.

3.        Gaudron P.J., Eilles C., Ertl G. Subacute adaptation to loss of contraqtil myocardium by left ventricular  dilitation (re­modeling) in patient with myocardial infarction // Grc. 1987, 76, Suppol. IV, 102 Absstr.

4.         Kober L. , Torp-Pedersen C. Et al A clinical trial of the angiotensinconverting enzyme inhibitor in patient with left ventricular   dysfunction after myocardial infarction // N. Engl. J. Med. 1995, 333, 25, 1670-1676.

5.        Mi­chel J.B. Experimental myocardial infarction in the rat. Effect of perindopril // Arch.Mal. Coeur Vaiss. 1991, 84, 51-61.

6.       Pfeffer M.A., Braunwald E. Ventricular remodeling after myocardial infarction: experimental observation and cli­ni­cal implications // Circ. 1990, 81,, 1161-1172.

 

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