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The problem of genetic and other factors on the genesis |
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Special study was carried out involving 40 patients with silent myocardial ischemia using those tests and genetic methods that make possible explain precise mechanism of the development of SMI. The data obtained in the result of the study is as follows: intraverial tendencies and low level of neurotism are manifested in the case of SMI. In comparison with the typical cases of angina pectoris, the high threshold of pain perception and subthreshold intensity of ischemia condition SMI episodes. Thus, the mechanisms of developing of SMI are inhomogenous. The same patient may have several mechanisms of SMI. The analysis of structural-quantitative disorders of chromosomes showed that in 20% cases SMI in the contrast to the cases of typical ischemic disease is proceeding on the background of unstable chromosome system. Besides, in the case of SMI the transcriptive activity of nucleous organizers is deteriorated (lower). Such condition points at lowering of synthesis processes and increasing of chromosomes instability level and therefore indicates existence of corresponding disorder in those loci of genetic system, which are responsible for the corrected interrelation of pain perceptive protein substances. Thus, at revealing of SMI cases the family members of the patients (parents, sisters / brothers, children) should be examined using corresponding tests, as they also may have high risk of the development of disease. The study of characteristic peculiarities of patients showed, that the impact of those environmental factors, which, through directly effect can cause disorders in pain percepting neurochemical mechanisms have great importance role. Therefore,pain perception is effected not only by characteristic constitutional, environmental and other harmful factors but by hereditary. |
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